The properties of disulphide bonds relevant to their roles in stabilizing protein conformation are reviewed. Natural disulphides can stabilize folded conformations substantially, in some cases to much greater extents than would be expected from just entropic effects on the unfolded state. The linkage relationship between conformational stability and disulphide stability is illustrated. Disulphides will not, however, increase protein stability if the disulphides are not maintained in the unfolded state or if instability is caused by processes, such as chemical modification or (...) proteolysis, that are not linked to unfolding, either local or global. This is part of the reason why some recent attempts to increase protein stability by introducing new disulphides have had only modest success. Other reasons appear to be the severe energetic constraints on disulphide bond geometry and, in some cases, unfavourable effects of introducing Cys residues by mutation. (shrink)

The best‐characterized model pathway of protein folding, that of disulphide bond formation in the small protein BPTI, has been questioned recently. A reinvestigation of that pathway, using alternative methods, concluded that the intermediates with non‐native disulphide bonds accumulated to lower levels than previously had been observed(17). On this basis, a revised pathway was proposed that simply omitted those intermediates. Even if totally correct, however, the new observations are not inconsistent with the important characteristics of the original pathway and even confirmed (...) many of them. Certain crucial observations that were the experimental basis for the original pathway were ignored, and these observations invalidate the revised pathway. (shrink)

In _Evidence and Transcendence_, Anne Inman critiques modern attempts to explain the knowability of God and points the way toward a religious epistemology that avoids their pitfalls. Christian apologetics faces two major challenges: the classic Enlightenment insistence on the need to provide evidence for anything that is put forward for belief; and the argument that all human knowledge is mediated by finite reality and thus no “knowledge” of a being interpreted as completely other than finite reality is possible. Modern Christian (...) apologists have tended to understand their task primarily, if not exclusively, in terms of one of these challenges. As examples of contemporary rationalist and postliberal approaches, Inman analyzes in depth the religious epistemologies of philosopher Richard Swinburne and theologians George Lindbeck and Ronald Theimann. She concludes that none of their positions is satisfactory, because none can uphold the notion of God’s transcendence while at the same time preserving a sound account of our claims to freedom and knowledge. The root cause of such failures, Inman argues, is an inadequate philosophy of God and of the relation of God and the finite world. Her exploration of the theologies of Karl Rahner and Friedrich Schleiermacher provides the material for the constructive work in this book. Against rationalist and postliberal epistemologies, Inman calls for an austere grounding of Christian faith in the claim that God is known in human conscious activity as such, as the “other” that grounds the finite. “An invaluable contribution to theology. It illuminates central issues of theology: the understanding of God, the demand for evidence, the rationality of Christian belief, and the relationship between philosophy and theology. It presents an excellent survey of several major theological approaches and offers a balanced proposal that seeks to incorporate the best from each approach. A must read for anyone interested in current approaches to God and Christian belief.” —_Francis Schüssler Fiorenza, Stillman Professor of Roman Catholic Theological Studies, Harvard Divinity School_ “_Evidence and Transcendence_ addresses a critically important topic: the need for evidence and the insistence on the mediation of knowledge. Anne Inman’s ambitious project makes an original contribution to the field by framing the problem very well and bringing in a variety of thinkers to analyze it. The book will be welcomed by students and scholars of systematic theology and philosophy of God.” —_Thomas M. Kelly, Creighton University_. (shrink)

The question of how to define the concept of social power has been a focus of controversy among social theorists. In this paper, I put forward a definition of social power that avoids many of the pitfalls of previous attempts at such a definition. Roughly, I define the power which one agent has over another as the ability that the dominant agent has to control the situation within which the subservient agent acts. Using this basic definition of power, I go (...) on to define many of the central forms in which power actually exists, forms that are conceptualized by such concepts as force, coercion, and influence. I show that these different forms of power can all be understood as specifications of the generic definition of power that I offered and go on to develop an account of how they function in relation to one another in actual relationship of social power. (shrink)

Thomas E. Hill, Jr.; Servility and Self-Respect, The Monist, Volume 57, Issue 1, 1 January 1973, Pages 87–104, https://doi.org/10.5840/monist197357135.

Thomas Hill, a leading figure in the recent development of Kantian moral philosophy, presents a set of essays exploring the implications of basic Kantian ideas for practical issues. The first part of the book provides background in central themes in Kant's ethics; the second part discusses questions regarding human welfare; the third focuses on moral worth-the nature and grounds of moral assessment of persons as deserving esteem or blame. Hill shows moral, political, and social philosophers just how valuable moral (...) theory can be in addressing practical matters. (shrink)

Back to Kant is a study of the rise of the neo-Kantian movement from its origins in the 1850s to its academic preeminence in the years before World War I. Thomas E. Willey describes early neo-Kantianism as a reaction of scientists and scientific philosophers against both the then discredited Hegelianism and Naturphilosophie of the preceding era and the simplistic and deterministic scientific materialism of the 1850s. "Back to Kant" was the slogan of a revolt against theories of knowledge which (...) seemed inadequate to recent discoveries in thermodynamics, physiology, optics and other fields. Because Immanuel Kant was the philosopher who placed Newtonian physics on new epistemological foundations and demonstrated the possibility of universal scientific truth, he was the right thinker for a generation of scholars living through a new scientific revolution in Germany and dissatisfied with both speculative idealism and crude materialism. The second wave of neo-Kantians continued to discuss problems of scientific epistemology in the 1880s and after, but they also showed a keen interest in political and social matters, attempting to bridge liberalism and socialism with Kantian ethics. Neo-Kantians had to face questions of socialism, the place of the working class in society, the phenomenon of social welfare, the challenge of political democracy. Willey uses the biographical approach to develop the relationship between unity and diversity in the movement, and to underscore the importance of personality in history. While individual dissertations and monographs have been written on various thinkers and schools within neo-Kantianism, this is the first wide-ranging history of the entire phenomenon. Willey observes that the movement did succeed in reasserting ethical values and in separating humanistic studies from the methods of physical science. He also discusses the possibility that a wider acceptance of neo-Kantian ideals among bourgeois intellectuals and socialist leaders might have reduced class antagonisms and sustained a stronger feeling of community between Germany and the West. (shrink)

The tendency to attribute foundationalist ambitions to the Vienna Circle has long obscured our view of its attempted revolution in philosophy. The present paper makes the case for a consistently epistemologically anti-foundationalist interpretation of all three of the Circle's main protagonists: Schlick, Carnap, and Neurath. Corresponding to the intellectual fault lines within the Circle, two ways of going about the radical reorientation of the pursuit of philosophy will then be distinguished and the contemporary potential of Carnap's and Neurath's project explored.

Released in 1999, _Fight Club_ is David Fincher’s popular adaption of Chuck Palahniuk’s cult novel, and one of the most philosophically rich films of recent years. This is the first book to explore the varied philosophical aspects of the film. Beginning with an introduction by the editor that places the film and essays in context, each chapter explores a central theme of _Fight Club_ from a philosophical perspective. Topics discussed include: _Fight Club_, Plato’s cave and Descartes’ cogito moral disintegration identity, (...) gender and masculinity visuals and narration. Including annotated further reading at the end of each chapter, _Fight Club_ is essential reading for anyone interested in the film, as well as those studying philosophy and film studies. (shrink)

Leo Lionni's charming tale of a mouse, eponymously named Frederick, raises very important questions about the nature of work, a topic addressed in the field of social and political philosophy. A question — one that the mice themselves raise — is whether Frederick is doing work when he gathers the sun, colors, and words. Since the book has used the word “gather” as its way of conceptualizing work, it might seem that Frederick is working, for he, too, is also gathering (...) things, just not the things that all the other mice do. Alternatively, we can say that even though Frederick is doing intellectual, rather than physical work, both types of work are necessary for the continued existence of anything but the most simple society. Children have differing opinions about whether Frederick was working or was just being a slacker. (shrink)

The prelims comprise: Half‐Title Page Title Page Copyright Page Dedication Page Table of Contents Acknowledgments.

There are many ways of writing about the moral life, but at first sight few seem more formal and apparently remote from its urgent, anguishing problems than ...

I examine the thesis that Otto Neurath anticipated the programme of naturalised epistemology already at the time of the Vienna Circle and consider the relation between Neurath's proposals and those of two contemporary theorists whose research programmes he would thus have broadly anticipated. The thesis is confirmed by reference to Neurath's own writings. The connection between Neurath's programme and the programmes of his two successors considered here, however, is found to be highly indirect in one case and nonexistent in the (...) other — despite their undeniable overlap. (shrink)

Logical Empiricism is commonly regarded as uninterested in, if not hostile to sociological investigations of science. This paper reconstructs the views of Otto Neurath and Philipp Frank on the legitimacy and relevance of sociological investigations of theory choice. It is argued that while there obtains a surprising degree of convergence between their programmatic pronouncements and the Strong Programme, the two types of project nevertheless remain distinct. The key to this differences lies in the different assessment of a supposed dilemma facing (...) post-Mertonian sociologists of science. (shrink)

Thoughtful Images: Philosophy Illustrated is the first systematic investigation of how artists throughout the ages have illustrated philosophical texts, ideas, concepts, and theories. The book begins by developing a theory of visual illustrations of philosophical texts and undermining what the author calls "the denigration of illustration." The book then takes a more historical approach, beginning in Ancient Greece and Rome and proceeding through Medieval illuminations and printed broadsides to the frontispieces of philosophical texts. Throughout, attention is paid to how technological (...) developments enable different means for illustrating philosophy. (shrink)

Respect, Pluralism, and Justice is a series of essays which sketches a broadly Kantian framework for moral deliberation, and then uses it to address important social and political issues. Hill shows how Kantian theory can be developed to deal with questions about cultural diversity, punishment, political violence, responsibility for the consequences of wrongdoing, and state coercion in a pluralistic society.

Bezugnehmend auf Kants Moralphilosophie entwickelt dieser Beitrag eine These dazu, was mit der Forderung gemeint sein soll, Personen unter Beachtung ihrer Würde bzw. als "Zweck an sich selbst" zu behandeln. Es wird vorgeschlagen, die Implikationen von Kants "Menschheitsformel" als ein Bündel von mit einander verwandten Vorschriften zu interpretieren, die das moralische Nachdenken darüber, wie die Prinzipien unserer tagtäglichen Entscheidungen spezifiziert und interpretiert werden sollten, leiten und begrenzen können. Der Beitrag bearbeitet sodann die folgenden drei Fragestellungen: Was folgt aus dem Vorangehenden (...) im Hinblick auf die Behandlung von Straftätern bei der Verbüßung ihrer Strafe? Was empfiehlt die "Menschheitsformel" - einmal abgesehen von Kants "offizieller" Straftheorie - im Hinblick darauf, wer, wie stark, in welcher Weise und warum bestraft werden sollte? Gibt es Konflikte zwischen diesen Empfehlungen und Kants "offizieller" Straftheorie, die eine Revision seiner Gründe für diese Theorie erforderlich machen? Drawing from Kant's moral theory, this essay develops an account of what is required to treat persons with dignity, or as "ends in themselves". It proposes to regard the implications of Kant's humanity formula as a cluster of related precepts that can guide and constrain moral deliberation about how to specify and interpret the principles that should guide day to day decisions. The essay then addresses three questions: What is implied regarding how offenders should be treated while undergoing punishment? Apart from Kant's official theory of punishment, what would the humanity formula recommend regarding who should be punished, how much, in what way, and why? Are there conflicts between these recommendations and Kant's official theory of punishment that invite reexamination of his grounds for his official theory? (shrink)

It is a violation of legitimate academic freedom to attempt to link Catholicism to a particular school of economic thought and shut down all further debate. Whether the realm of human choice, which economics describes, is subject to an array of cause-and-effect relationships is obviously a matter for human reason to determine. From there, reason can then investigate these relationships. Although economic policy has a moral dimension, economics as a positive scienceconsists merely of an edifice of cause-and-effect relationships, and to (...) that extent is as autonomous as the purely descriptive sides of all other sciences. (shrink)

Through a collection of new, previously unpublished essays, _The_ _Blackwell Guide to Kant’s Ethics_ addresses diverse topics crucial to our understanding of Kant's moral philosophy and its implications for the modern age. Provides a fresh perspective on themes in Kant’s moral philosophy Addresses systematically Kant’s foundational work, _Groundwork for the Metaphysics of Morals_ and his more specific treatment of justice and virtue in _The Metaphysics of Morals_ Includes essays by both established scholars and rising stars Identifies common misperceptions of Kant's (...) thought and challenges some prevailing interpretations Shows how Kant developed and supplemented his earlier ethical thought with specific discussions of practical issues in law, international relations, personal relations, and self-regarding virtues and vices. (shrink)

_Taking Picture Books Seriously: What can we learn about philosophy through children's books?_ This warm and charming volume casts a spell on adult readers as it unveils the surprisingly profound philosophical wisdom contained in children's picture books, from Dr Seuss's _Sneetches_ to William Steig's _Shrek!_. With a light touch and good humor, Wartenberg discusses the philosophical ideas in these classic stories, and provides parents with a practical starting point for discussing philosophical issues with their children. Accessible and multi-layered, it answers (...) questions like, Is it okay for adults to deceive kids? What's the difference between saying the Mona Lisa is a great painting and vanilla is your favorite flavor? Each chapter includes illustrations commissioned especially for this book. (shrink)

Reviews the role of happiness in Kant's moral and political philosophy and contrasts his ideas of happiness with ideas of human flourishing prominent in ancient philosophy. It considers possible reasons why Kant avoided the latter and worked instead with more subjective conceptions of happiness. This was apparently due not merely to historical influences or misunderstanding of ancient ethics but also to Kant's respect for the moral freedom of individuals to choose, within limits, the way of life they prefer. Kant's understanding (...) of happiness affects his ideas of intrinsic value, prudence, beneficence, and the aim of government. Michael Slote's charge that Kantian ethics requires us to devalue our own happiness relative to others’ arguably rests on a flawed analogy between beneficence to others and promoting one's own happiness. (shrink)

This response considers the question whether empiricists are condemned to silence about the epistemic agency their theories attribute or presuppose. It is argued that, unlike Reichenbach or Carnap, Neurath allowed for and indeed provided specifications of the role of epistemic agency in scientific inquiry. If this is correct, it underscores once more the need to distinguish between the various strands of logical positivism which show different strengths and weaknesses.

In this book Thomas Wren uncovers and assesses the largely hidden philosophical assumptions about human motivation that have shaped contemporary psychological ...

This contrasts Kant's view of conscience, and its merits, with alternative views. These alternatives are a popular religious view, a social relativist conception, and Joseph Butler's philosophical account. Kant's view avoids the epistemological problems of the first view, but accepts its idea that conscience is often experienced as an unsolicited voice. Kant denies the metaethical scepticism of social relativists, but agrees with them that conscience expresses a dissonance between our acts and our moral beliefs rather than an independent perception of (...) what is truly right or wrong. Kant agrees with Butler that reason, in due reflection, is the source of justified moral beliefs, but he distinguishes moral reasoning and judgement about what acts are permissible from conscience, which is an inner forum in which a verdict of innocence or guilt is pronounced on the basis of the moral beliefs that we already have. (shrink)

In The Metaphysics of Morals Kant suggests that the bad results of wrongful acts can always be imputed to the agent but the bad results of dutiful acts can never be. Although Kant's concern in the context was apparently legal imputation, the article considers how Kant's doctrine might apply to questions about moral responsibility for bad consequences in cases where legal enforcement is inappropriate. First , interpretative questions are addressed. For example, does imputation imply being to blame for bad results (...) or merely being liable to compensate for them? What are the criteria for bad results? What is the relation between assessments of responsibility for bad consequences and judgments of the moral worth or desert of the agent? Is the operative notion of "results" or "consequences" a descriptive or normative one? The suggestion is that liability, not blame, is what is crucial, and wrong-doers are responsible for whatever bad causally results from their misdeeds, whether it was foreseeable or not. Second , putative counter-examples to Kant's doctrine are evaluated: for example, cases where it seems an agent may be liable for bad consequences even when doing what is permissible, dutiful, or even meritorious. Although many of the objections fail to survive examination, there remain cases where bad results of a wrongful act cannot plausibly be imputed to the agent and other cases where the agent seems clearly liable for bad results despite having acted innocently. Such intuitive objections, however, must be reviewed from a larger perspective of a systematic moral theory. In der Metaphysik der Sitten nimmt Kant an, daß die schlechten Folgen einer pflichtwidrigen Handlung dem Handelnden stets zugerechnet werden können, im Gegensatz zu den schlechten Folgen pflichtgemäßer Handlungen, die dem Handelnden niemals zugerechnet werden können. Obwohl es Kant im Kontext der Metaphysik der Sitten offensichtlich auf die juridische Zurechnung ankommt, geht es im vorstehenden Beitrag um die Frage, ob sich Kants Lehre auf die moralische Verantwortlichkeit für schlechte Folgen in denjenigen Fällen übertragen läßt, in denen eine juridische Normdurchsetzung unpassend ist. Und zwar geht es erstens um eine angemessene Interpretation der einschlägigen Textstellen selbst. Etwa: Meint "Zurechnung", daß der Handelnde für die schlechten Folgen seiner Handlung zu tadeln ist, oder meint "Zurechnung" lediglich seine Haftung für den angerichteten Schaden? Was sind die Kriterien dafür, Folgen als "schlechte" Folgen zu bezeichnen? Welches Verhältnis besteht zwischen der Zurechnung von Verantwortlichkeit für schlechte Folgen und dem Urteil über den moralischen Wert oder das moralische Verdienst des Handelnden? Ist "Folge" als operativer Begriff deskriptiv oder normativ zu verstehen? Der Beitrag geht davon aus, daß Haftung, und nicht Tadel, das eigentlich Entscheidende ist und daß, wer pflichtwidrig handelt, für alles Schlechte verantwortlich ist, das von seinen Taten verursacht wird, und zwar gleichgültig, ob es vorhersehbar war oder nicht. Zweitens geht es um vermeintliche Gegenbeispiele zu Kants Theorie. Etwa: Es werden Fälle erörtert, bei denen es so zu sein scheint, daß der Handelnde auch für solche schlechten Folgen haftet, die aus einem erlaubten, einem pflichtgemäßen oder sogar aus einem verdienstlichen Handeln herrühren. Obwohl viele Einwände einer näheren Überprüfung nicht standhalten, gibt es doch Fälle, bei denen die Zurechnung der schlechten Folgen einer pflichtwidrigen Handlung immer noch als unplausibel, und andere Fälle, bei denen die Zurechnung der schlechten Folgen einer nicht pflichtwidrigen Handlung immer noch als notwendig erscheint. Solche intuitiven Einwände sind von dem höheren Standpunkt einer systematischen Moraltheorie aus zu beantworten. (shrink)

This essay, responding to recent work of David Cummiskey and Barcia Baron, defends the thesis that imperfect duty of beneficence in Kant's The Metaphysics of Morals is a rather minimal, indeterminate requirement but must be supplemented by judgement guided by the values expressed in Kant's formulas of the Categorical Imperative. So understood, Kant's ethics is neither as permissive nor as inflexibly demanding as various commentators have thought. Although Kant does not acknowledge supererogation as a moral category, arguably his position implies (...) that some acts are meritorious and more than required. (shrink)

The contributors to this volume describe a range of programs that use picture books to teach philosophy to diverse audiences. From a pre-school program in which college students to do the teaching to a program focused on overcoming the legacy of violence and genocide in Mali in which the teachers write and illustrate their own picture books, the authors demonstrate the impact that learning philosophy has on diverse communities of young students and their teachers.

Deacon presents a fascinating model that adds to explanations of the origins of life from physical matter. Deacon’s paper owes much to the work of Howard Pattee, who saw semiotic relations in informational terms, and Deacon binds his model to criticism of current information concepts in biology which he sees as semantically inadequate. In this commentary I first outline the broader project from Pattee, and then I present a cybernetic perspective on information. My claim is that this view of information (...) is already present within biology and provides what Deacon seeks. (shrink)

Kant is often regarded as an extreme retributivist, but recently commentators emphasize the importance of deterrence in Kant's basic justification of punishment. Kant's combination of deterrence and retributive elements, however, must be distinguished from others that are less plausible. To interpret Kant as merely adding retributive side-constraints to a basic deterrence aim fails to capture fully the retributive strain in Kant's thought. The basic questions are: who should be punished, how much, in what manner, and why? Kant held that all (...) and only the legally guilty ought to be punished, the legally guilty being also morally guilty, except when the legal requirement was to do something "immoral in itself." This case aside, violations of law also transgress an ethical duty to obey the law. Criminal punishments should be designed to match victims' empirically discernable losses in degree and kind, except when this would be impossible or degrading; courts cannot measure the ultimate moral desert of criminals, which depends on their inner "will." "Punishment" is not a mere disincentive in a "price" system of social control; it has an inherent expressive function, conveying a public message of moral disapproval of the criminal conduct in question. Understanding this together with Kant's basic theory of justice may help to explain his acceptance of ius talionis and condemnation of making exceptions for pragmatic reasons. It also accounts for the retributive "tone" of Kant's remarks, despite his insistence that public courts deal only with "external actions," not overall moral worth and character assessment. Kant wird oft als Vertreter einer extremen Vergeltungstheorie gesehen. Auf der anderen Seite betonen verschiedene Autoren in der letzten Zeit die Abschreckung als grundlegendes Element in Kants Rechtfertigung der Strafe. Ihnen gegenüber muß Kants Verknüpfung von Vergeltung und Abschreckung von anderen ähnlichen Verknüpfungen unterschieden werden, die weniger plausibel sind. Kant so zu interpretieren, als füge er zum Hauptziel der Abschreckung nur einige nebensächliche Elemente der Vergeltung hinzu, verfehlt den Vergeltungsaspekt in Kants Straftheorie. Die grundlegenden Fragen sind: Wer soll bestraft werden, wie schwer, in welcher Weise und warum? Kant war der Ansicht, daß alle, aber auch nur diejenigen bestraft werden sollen, die sich vor dem juridischen Gesetz schuldig gemacht haben. Wer sich vor dem juridischen Gesetz schuldig gemacht hat, hat sich auch moralisch schuldig gemacht, es sei denn, das vom Recht Geforderte sei etwas "an sich selbst Unmoralisches". Sieht man von diesem letzteren Fall einmal ab, dann enthält jede Übertretung des juridischen Gesetzes immer auch eine Verletzung der ethischen Pflicht, dem juridischen Gesetz zu gehorchen. Strafe sollte darauf angelegt sein, den empirisch erkennbaren Verlusten des Opfers nach Art und Ausmaß zu entsprechen, außer, wenn dies unmöglich oder erniedrigend wäre; Gerichte können die tatsächliche moralische Schuld von Verbrechern, die von ihrem inneren "Willen" abhängt, nicht messen. "Strafe" ist kein bloßes Abschreckungsmittel in einem "Preis"-System sozialer Kontrolle. Statt dessen hat sie die ganz wesentliche und ausdrückliche Funktion, die moralische Mißbilligung des jeweiligen verbrecherischen Verhaltens öffentlich zum Ausdruck zu bringen. Diese Interpretation, zusammen mit Kants grundlegender Theorie der Gerechtigkeit, kann helfen zu verstehen, warum Kant das ius talionis akzeptiert hat und warum er Ausnahmen, die aus pragmatischen Gründen gemacht werden, mißbilligt. Sie erklärt auch den "Tonfall" in Kants Äußerungen, der mir seiner Vergeltungstheorie zusammenhängt, auch wenn Kant darauf beharrt, daß staatliche Gerichte sich immer nur mit "äußeren" Handlungen befassen, nicht mit dem moralischen Wert insgesamt oder mit einer Beurteilung des Charakters einer Person. (shrink)

While this Journal is not the place for an extended discussion of the exegeticalpoints raised by Thomas Oberdan’s ‘The Vienna Circle’s ‘‘Anti-Foundation-alism’’’ [1998], some brief remarks are required to correct his misunderstand-ing of my position on the relevant issues, to stress the highly controversialstatus of his own interpretation and to counter his portrayal of the dialectics ofthe debate.